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2021 Epigenomics-UK

DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes.

Garcia-Ruiz B, de Moura MC, Muntané G, Martorell L, Bosch E, Esteller M, J Canales-Rodríguez E, Pomarol-Clotet E, Jiménez E, Vieta E, Vilella E

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Abstract

To investigate methylation in the brains of bipolar disorder (BD) patients and its association with mRNA levels and comethylation with myelin genes. Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. 5-methylcytosine levels were increased and directly associated with b mRNA expression in the brains of BD patients. We also observed that was comethylated with a group of myelin genes. is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, comethylation with myelin genes supports the role of this receptor in myelination.