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23831342

2014 Biological Psychiatry

APOE Genotype Modulates Proton Magnetic Resonance Spectroscopy Metabolites in the Aging Brain.

Gomar JJ, Gordon ML, Dickinson D, Kingsley PB, Uluğ AM, Keehlisen L, Huet S, Buthorn JJ, Koppel J, Christen E, Conejero-Goldberg C, Davies P, Goldberg TE

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Abstract

Proton magnetic resonance spectroscopy ((1)H-MRS) studies on healthy aging have reported inconsistent findings and have not systematically taken into account the possible modulatory effect of APOE genotype. We aimed to quantify brain metabolite changes in healthy subjects in relation to age and the presence of the APOE E4 genetic risk factor for Alzheimer's disease. Additionally, we examined these measures in relation to cognition.