Publications - FIDMAG, Fundation for research

COOKIES USE
We use necessary system cookies for the correct functioning of the website and optional Google Analytics cookies to obtain visit statistics. +info

Cookies config

Necessary

The necessary cookies are absolutely essential for the website to work properly. This category only includes cookies that guarantee basic website security and functionality. These cookies do not store any personal information.

Name	Proveedor	Propiedad	Finalidad	Caducidad
_GRECAPTCHA	google.com	Own	provide antispam protection with the reCaptcha service	6 months
cc_cookie_accept	fidmag.org	Own	Usada per confirmar que l'usuari ha confirmat / refusat les cookies (i quins tipus accepta)	1 any
WEB_SESSION	fidmag.org	Own	Cookie técnica: cookie de sessió PHP. Guarda l'id de sessió d'usuari.	al acabar la sessió

Analisys

Analytical cookies are used to understand how visitors interact with the website. These cookies help to provide information on meters, the name of visitors, the percentage of bounces, the font of the traffic, etc.

Name	Proveedor	Propiedad	Finalidad	Caducidad
_ga	Google Analytics	From third parties	Cookie d'anàlisi o mesurament: Identifica els usuaris i proporciona informació sobre com els usuaris troben la pàgina web i com la utilitzen per a realització d'Informes estadístics	2 anys
_gat_gtag_UA_141706552_1	Google Analytics	From third parties	Cookie d'anàlisi o mesurament: Tracking per part de google per google analytics	1 minut
_gid	Google Analytics	From third parties	Cookie d'anàlisi o mesurament: S'usa per limitar el percentatge de sol·licituds	24 hores

Configure Reject all Accept

Home
> Research

Back to results

FI
8.802

22910680

2012 Neuroscience and Biobehavioral Reviews

Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication

Radua J, Borgwardt S, Crescini A, Mataix-Cols D, Meyer-Lindenberg A, McGuire PK, Fusar-Poli P

Limited service to collaborators of the network of Sisters Hospitalarias Centers. You will receive a message in your email with a link to download this article.

Abstract

Structure and function in the human brain are closely related. At the onset of psychosis, brain imaging studies have identified robust changes in brain function and structure, but no data are available relating these two domains. After systematic literature searches, we included all available studies reporting whole-brain structural or cognitive functional imaging findings in first-episode (FEP) subjects in multimodal Signed Differential Mapping (SDM). Forty-three studies met the inclusion criteria. The structural database comprised 965 FEP subjects matched with 1040 controls whilst the functional cohort included 362 FEP subjects matched with 403 controls. The analysis identified conjoint structural and functional differences in the insula/superior temporal gyrus and the medial frontal/anterior cingulate cortex bilaterally. In these regions, large and robust decreases in grey matter volume were found with either reduced or enhanced activation. Meta-regression analyses indicated that grey matter volume in the anterior cingulate and left insular clusters was influenced by exposure to antipsychotics: patients receiving medication were more likely to show structural abnormalities in these regions.