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14.496

22614292

2013 Molecular Psychiatry

The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder

Radua J, Surguladze SA, Marshall N, Walshe M, Bramon E, Collier DA, Prata D, Murray RM, McDonald C

Limited service to collaborators of the network of Sisters Hospitalarias Centers. You will receive a message in your email with a link to download this article.

Abstract

The A allele of the CACNA1C rs1006737 polymorphism is consistently
associated with bipolar disorder (BD). No studies have examined the
relationship between this polymorphism and brain connectivity, which is
disrupted in BD. We investigated the relationship between rs1006737
polymorphism and effective connectivity in BD families. During perception of
fearful faces, the presence of the A risk allele was associated with decreased
outflow of information from medial frontal gyrus, which was significantly more
marked in patients than in their unaffected relatives and healthy controls.