US DE COOKIES
Utilitzem cookies necessaries de sistema pel correcte funcionament de la web i cookies opcionals de Google Analytics per obtenir estadístiques de visita (sense obtenir dades personales). + Info
Acceptar cookies
Tornar als resultats
FI
3.923
2022 Schizophrenia Research
Clinical and treatment predictors of relapse during a three-year follow-up of a cohort of first episodes of schizophrenia.
Bioque M, Mezquida G, Amoretti S, García-Rizo C, López-Ilundain JM, Diaz-Caneja CM, Zorrilla I, Mané A, Rodriguez-Jimenez R, Corripio I, Pomarol-Clotet E, Ibáñez Á, Usall J, Contreras F, Mas S, Vázquez-Bourgon J, Cuesta MJ, Parellada M, González-Pinto A, Hidalgo-Figueroa M, Bernardo M

Servei limitat a col·laboradors/res de la xarxa de centres de Germanes Hospitalàries. Rebreu un missatge al vostre correu-e amb un enllaç per a la descàrrega del present article.

Abstract

Relapses are frequent in the first years following a first episode of schizophrenia (FES), being associated with a higher risk of developing a chronic psychotic disorder, and poor clinical and functional outcomes. The identification and intervention over factors associated with relapses in these early phases are timely and relevant. In this study, 119 patients in remission after a FES were closely followed over three years. Participants came from the 2EPS Project, a coordinated, naturalistic, longitudinal study of 15 tertiary centers in Spain. Sociodemographic, clinical, treatment and substance abuse data were analyzed. 49.6% of the participants relapsed during the 3-years follow-up. None of the baseline demographic and clinical characteristics analyzed showed a statistically significant association with relapses. 22% of patients that finished the follow-up without relapsing were not taking any antipsychotic. The group that relapsed presented higher mean antipsychotics doses (381.93 vs. 242.29 mg of chlorpromazine equivalent/day, p = 0.028) and higher rates of antipsychotic polytherapy (28.6% vs. 13%, p < 0.001), benzodiazepines use (30.8% vs. 8.5%, p < 0.001), side effects reports (39.2% vs. 25%, p = 0.022), psychological treatment (51.8% vs. 33.9%, p = 0.03), and cannabis consumption (93.2% vs. 56.7%, p < 0.001). Clozapine use was notably higher in the group that reminded in remission (21.7% vs. 8.2%, p < 0.019). These findings may guide clinicians to detect subgroups of patients with higher risk to present a second episode of psychosis, focusing on measures to ensure an adequate treatment or facilitating cannabis use cessation. This study supports future research to identify relapse prevention strategies for patients in early phases of schizophrenia.
Formem part de
HH Província Espanya
Contacteu-nos

Avda. Jordà , 8 - 08035 Barcelona
Telèfon: 93 548 01 05
E-mail: fundacio@fidmag.com
Formulari de contacte online 

         

 

Reconeixements a la qualitat i l'excel·lència
Darrera modificació: 02/08/2022
AGAUR
CIBERSAM
Generalitat de Catalunya
ISCIII
Logo UE 2022
MICINN