US DE COOKIES
Utilitzem cookies necessaries de sistema pel correcte funcionament de la web i cookies opcionals de Google Analytics per obtenir estadístiques de visita (sense obtenir dades personales). + Info
Acceptar cookies
Tornar als resultats
FI
3.957
2021 Journal of Psychiatric Research
Patrones de activación y desactivación cerebral en la esquizofrenia durante la ejecución de una versión del test de Stroop adaptada a la RMf
Salgado-Pineda P, Rodriguez-Jimenez R, Moreno-Ortega M, Dompablo M, Martínez de Aragón A, Salvador R, McKenna PJ, Pomarol-Clotet E, Palomo T

Servei limitat a col·laboradors/res de la xarxa de centres de Germanes Hospitalàries. Rebreu un missatge al vostre correu-e amb un enllaç per a la descàrrega del present article.

Abstract

The Stroop task, which examines an aspect of executive function/cognitive control, the ability to inhibit prepotent responses, has been relatively little examined in schizophrenia, and the findings have been inconsistent. Whether performance of this task is associated with failure of de-activation in the disorder is also uncertain. We examined 42 schizophrenic patients and 61 healthy controls during performance of an fMRI-adapted version of the Stroop task, the counting Stroop task. Task-related activations (incongruent > congruent condition) and de-activations (baseline > incongruent) were examined using whole-brain, voxel-based methods. In the healthy controls, task performance was found to be associated with activations in the left dorsolateral prefrontal cortex and the dorsal anterior cingulate cortex, among other regions. De-activations were seen in the medial frontal cortex, the middle and posterior cingulate gyrus and cuneus, the parahippocampal gyrus and the hippocampus. The schizophrenic patients did not show reduced activation compared to the healthy controls. They did, however, show failure of de-activation in the medial frontal cortex. Our negative finding with respect to hypoactivation during performance of a task requiring inhibition of prepotent responses suggests that brain functional abnormality in schizophrenia may not affect all aspects of executive function/cognitive control. The finding of medial frontal cortex failure of de-activation adds to existing findings of default mode network dysfunction in the disorder.
Formem part de
HH Província Espanya
Contacteu-nos

Avda. Jordà , 8 - 08035 Barcelona
Telèfon: 93 652 99 99 - Ext 1486
E-mail: fundacio@fidmag.com
Formulari de contacte online 

         

 

Reconeixements a la qualitat i l'excel·lència
Darrera modificació: 19/10/2021
AGAUR
CIBERSAM
Generalitat de Catalunya
ISCIII
Unión Europea
MICINN