Servei limitat a col·laboradors/res de la xarxa de centres de Germanes Hospitalàries. Rebreu un missatge al vostre correu-e amb un enllaç per a la descàrrega del present article.
Introduction: Circadian rhythms are reflected through sleep-wake patterns and chronotype. Patients with bipolar disorder (BD) frequently exhibit disrupted sleep patterns and a tendency for evening chronotype. Also, genetic risk factors for BD partially overlap with those influencing sleep traits. Lithium (Li), the first-line therapy for BD, stabilizes circadian rhythms and promotes morningness in responders (Rp). This study aimed to evaluate whether the polygenic burden of sleep-related traits is associated with Li response in BD patients.